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Review
Nature Medicine 7, 541 - 547 (2001)
doi:10.1038/87865
The cellular neurobiology of depression
Husseini K. Manji1, Wayne C. Drevets2 & Dennis S. Charney3
Abstract
Major depressive disorders, long considered to be of neurochemical origin, have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways may hold promise as new therapeutics for depression.
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