Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 7, 528 - 530 (2001)
doi:10.1038/87842
Polyglutamine and CBP: Fatal attraction?
Alexander McCampbell1 & Kenneth H. Fischbeck1
- Neurogenetics Branch National Institute of Neurological Disorders and Stroke Bethesda, Maryland, USA
e-mail: kf@codon.nih.gov
Abstract
The mutant proteins that cause polyglutamine disease bind CREB-binding protein (CBP), a key transcriptional co-activator for neuronal survival factors. This results in a loss of CBP-dependent transcription and may account for the neuronal degeneration associated with these diseases.
Eight hereditary neurodegenerative diseases are known to be caused by polyglutamine-repeat expansions1. The expansions make the mutant proteins toxic to neurons, possibly through abnormal interactions with polyglutamine tracts in other, normal proteins2.
To read this story in full you will need to login or make a payment (see right).
