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News and Views
Nature Medicine 7, 527 - 528 (2001)
doi:10.1038/87839
Inflammation and Alzheimer disease: The good, the bad, and the ugly
Stacie C. Weninger1 & Bruce A. Yankner1
- Department of Neurology, Harvard Medical School Division of Neuroscience Children's Hospital Boston, Massachusetts, USA
e-mail: bruce.yankner@tch.harvard.edu
Abstract
Inflammation is commonly believed to be a culprit in Alzheimer disease pathogenesis. Recent studies, however, indicate that certain aspects of the inflammatory response may have therapeutic potential (pages 612–618).
One of the characteristic pathological features of Alzheimer disease (AD) is a robust inflammatory response associated with extracellular deposition of amyloid 
- protein (A). It has been assumed that the inflammatory response is detrimental and might contribute to neuronal degeneration1.
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