1
St. Jude Children's Research Hospital Memphis, Tennessee, USA
2
University of Pittsburgh Pittsburgh, Pennsylvania, USA strom@pitt.edu
The transcription factor SXR mediates drug, xenobiotic and steroid induction of a major drug−metabolizing enzyme. Drugs such as paclitaxel (Taxol) can bind and activate this transcription factor and therefore regulate their own metabolism and efflux from cells. Manipulation of this pathway might lead to new ways to improve therapeutic efficacy and to minimize toxicity (584−590).
