A role for complement in transmissible spongiform encephalopathies
Franco Cardone
& Maurizio Pocchiari
Laboratory of Virology Istituto Superiore di Sanità Rome, Italy
pocchia@iss.it
Two recent studies implicate the complement system in prion disease pathogenesis, suggesting that there are multiple, non-exclusive pathways of neuroinvasion (pages 485−487 & 488−492).