Acute myelogenous leukemias are caused by point mutations as well as several different types of chromosomal translocations, but little is known about how these genetic defects lead to disruptions in hematopoiesis and eventual leukemogenesis. Two recent studies suggest that the resulting mutant gene products can alter function of the transcription factor C/EBP and tip the balance from differentiation toward cancer (pages 444−451).
the answer?
and tip the balance from differentiation toward cancer (pages 444−451).
