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Nature Medicine 7, 292 - 293 (2001)
doi:10.1038/85429
The neglected ion: HCO3-
Paul M. Quinton1
- Biomedical Sciences, UCR and Nancy Olmsted Chair in Pediatric Pulmonology, Department of Pediatrics, UCSD School of Medicine La Jolla, California, USA
e-mail: pquinton@ucsd.edu
Abstract
Most research into the function of the cystic fibrosis transmembrane conductance regulator has focused on its role in Cl- transport. New findings suggest that we may have been focusing on the wrong ion.
Cystic fibrosis (CF) is a recessive hereditary disease that results in the accumulation of thick mucus that clogs the lungs and interferes with the flow of digestive enzymes through the pancreas and to the small intestine. Other complications of CF are the abnormal secretions of sweat and saliva.
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