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Nature Medicine 7, 290 - 292 (2001)
doi:10.1038/85426
A role for fibronectin in self-repair after ischemic injury
Deane F. Mosher1
- University of Wisconsin Madison, Wisconsin, USA
e-mail: dfmosher@facstaff.wisc.edu
Abstract
Plasma fibronectin has been proposed to play a role in wound healing. Studies with conditional knockout mice, however, indicate that fibronectin has more to do with protecting cells from ischemic damage after stroke (pages 324-330).
Fibronectin was characterized more than a half century ago as the plasma protein 'cold-insoluble globulin.' Research on this glycoprotein surged in the 1970s when it was found that its expression was lost during malignant transformation1.
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