One of the major challenges of the mad cow disease epidemic is the need for a good diagnostic test, to identify people and animals that have been infected with the infectious form of prion before symptoms appear. Differential display analysis may have revealed a good candidate marker (pages 361-364).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Miele, G., Manson, J.C. & Clinton, J. A novel erythroid-specific marker of transmissible spongiform encephalopathies. Nature Med. 7, 361–364 (2001).
Will, R. et al. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet 347, 921–925 (1996).
Fischer, M.B., Roeckl, C., Parizek, P., Schwarz, H.P. & Aguzzi, A. Binding of disease-associated prion protein to plasminogen. Nature 408, 479–483 (2000).
Hill, A.F., Zeidler, M., Ironside, J. & Collinge, J. Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy. Lancet 349, 99 (1997).
Hilton, D.A., Fathers, E., Edwards, P., Ironside, J.W. & Zajicek, J. Prion immunoreactivity in appendix before clinical onset of variant Creutzfeldt-Jakob disease. Lancet 352, 703–704 (1998).
Blättler, T. et al. PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature 389, 69–73 (1997).
Montrasio, F. et al. Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science 288, 1257–1259 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Aguzzi, A. Blood simple prion diagnostics. Nat Med 7, 289–290 (2001). https://doi.org/10.1038/85423
Issue Date:
DOI: https://doi.org/10.1038/85423
