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Nature Medicine  7, 1298 - 1305 (2001)
doi:10.1038/nm1201-1298

Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosis

Benfang Lei, Frank R. DeLeo, Nancy P. Hoe, Morag R. Graham, Stacy M. Mackie, Robert L. Cole, Mengyao Liu, Harry R. Hill, Donald E. Low, Michael J. Federle, June R. Scott & James M. Musser
 
Figure 1 thumbnailFigure 1.
Homology of streptococcal Mac and human CD11b.

Full FigureFull Figure and legend (33K)		 Figure 2 thumbnailFigure 2.
Mac production by GAS and analysis of Mac antibody titers in patients with GAS disease.

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Figure 3 thumbnailFigure 3.
Mac-dependent inhibition of ROS production during phagocytosis.

Full FigureFull Figure and legend (67K)		 Figure 4 thumbnailFigure 4.
Mac inhibits phagocytosis and killing of GAS by human PMNs.

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Figure 5 thumbnailFigure 5.
Interaction of Mac with host cells and with CD16/Mac-1.

Full FigureFull Figure and legend (89K)		 Figure 6 thumbnailFigure 6.
Model of how streptococcal Mac modulates human CD16/Mac-1 function.

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