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Nature Medicine  7, 1288 - 1289 (2001)
doi:10.1038/nm1201-1288

A fresh facet for ouabain action

Georgios Scheiner-Bobis & Wilhelm Schoner

Institut für Biochemie und Endokrinologie Justus-Liebig-Universität Giessen Giessen, Germany
G.S.B. (georgios.scheiner-bobis@vetmed.uni-giessen.de) or W.S. (wilhelm.schoner@vetmed.uni-giessen.de)

Ouabain signaling through a plasma membrane can produce oscillations of intracellular calcium levels, resulting in translocation of the NF-kappaB transcription factor into the nucleus and gene activation. This is a previously unrecognized form of steroid action.

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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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