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Nature Medicine 7, 1178 - 1180 (2001)
doi:10.1038/nm1101-1178
A renaissance for the tumor immunosurveillance hypothesis
Lewis L. Lanier1
- Department of Microbiology and Immunology and the Cancer Research Institute University of California, San Francisco San Francisco, California, USA
e-mail: lanier@itsa.ucsf.edu
Abstract
Little was known about the function of T cells expressing the 
–T-cell receptor, until these cells were shown to protect against skin cancer. But what is the mechanism mediating this activity?
More than 40 years ago, Lewis Thomas and Macfarlane Burnet proposed that the immune system provided surveillance against cancer. Although the concept has been validated for tumors caused by viruses, it has been more difficult to demonstrate immunosurveillance against spontaneous and carcinogen-induced tumors.
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