Department of Medicine and Pharmacology and the Center for Experimental Therapeutics University of Pennsylvania School of Medicine Philadelphia, Pennsylvania, USA
brass@mail.med.upenn.edu
The etiology of thrombotic thrombocytopenic purpura (TTP), a severe blood disorder resulting from increased platelet activation, has been an enigma. The identification of ADAMTS as a protease that cleaves von Willebrand factor and the demonstration of ADAMTS mutations in families with inherited TTP suggest a molecular mechanism for the disease.
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