1
Department of Medicine and Immunology, University of Colorado Health Sciences Center and National Jewish Medical and Research Center Denver, Colorado, USA
2
Department of Psychiatry and Medicine, University of Colorado Health Sciences Center and National Jewish Medical and Research Center Denver, Colorado, USA
brian.kotzin@uchsc.edu
Systemic lupus erythematosus can cause various forms of central nervous system disorders, ranging from subtle cognitive dysfunction to life-threatening coma. How lupus autoantibodies target neurons and cause brain injury remains a mystery. New research suggests that a subset of autoantibodies to double-stranded DNA in lupus patients cross-reacts with the NMDA glutamate receptor, and produces neuronal injury and death. (pages 1189−1193)
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