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Letters to Editor
Nature Medicine 7, 1073 - 1074 (2001)
doi:10.1038/nm1001-1073
Immunophilin ligand FK506 is neuroprotective for penile innervation
Sena F. Sezen1, Ahmet Hoke2, Arthur L. Burnett1 & Solomon H. Snyder3
- Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
- Department of Neurology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
- Department of Neuroscience, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
e-mail: ssnyder@bs.jhmi.edu
Erectile dysfunction following radical prostatectomy is common even with presumably intact cavernous nerves, the principal autonomic innervation of the penis1. The immunosuppressant drugs FK506 and cyclosporin A act through their respective binding proteins FKBP12 and cyclophilin, collectively termed immunophilins2.
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