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Forbidden fruit

Although citrus fruits prevent and cure scurvy, they may not always be as good for you as you thought.

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References

  1. Tröhler, U. in To improve the evidence of medicine: The 18th century British origins of a critical approach. (Royal College of Physicians of Edinburgh, Edinburgh) 68–81 (United Kingdom, 2000).

    Google Scholar 

  2. Carr, A.C. & Frei, B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am. J. Clin. Nutr. 69, 1086–1107 (1999).

    Article  CAS  Google Scholar 

  3. National Research Council in Recommended dietary allowances. 10th edn (National Academic Press, Washington DC, 1989).

  4. Levine, M. et al. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc. Natl. Acad. Sci. USA 93, 3704–3709 (1996).

    Article  CAS  Google Scholar 

  5. Stewart, M.L., McDonald, J.T., Levy, A.S., Schucker, R.E. & Henderson, D.P. Vitamin/mineral supplement use: a telephone survey of adults in the United States. J. Am. Diet. Assoc. 85, 1585–1590 (1985).

    CAS  PubMed  Google Scholar 

  6. Gershoff, S.N. Vitamin C (ascorbic acid): new roles, new requirements? Nutr. Rev. 51, 313–326 (1993).

    Article  CAS  Google Scholar 

  7. Douglas, R.M., Chalker, E.B. & Treacy, B. Vitamin C for preventing and treating the common cold (Cochrane review) in The Cochrane Library. Update Software, Issue 3 (Oxford, UK, 2000).

    Google Scholar 

  8. Evans, J.R. & Henshaw, K. Antioxidant vitamin and mineral supplementation for preventing age-related macular degeneration (Cochrane review) in The Cochrane Library. Update Software, Issue 3 (Oxford, UK, 2000).

    Google Scholar 

  9. Kaur, B. Vitamin C supplementation asthma (protocol for a Cochrane review) in The Cochrane Library. Update Software, Issue 3 (Oxford, UK, 2000).

    Google Scholar 

  10. Blanchard, J., Tozer, T.N. & Rowland, M. Pharmacokinetic perspectives on megadoses of ascorbic acid. Am. J. Clin. Nutr. 66, 1165–1171 (1997).

    Article  CAS  Google Scholar 

  11. Basu, T.K. & Schorah, C.J. in Vitamin C in health and disease. (The Avi Publishing Company, Westport, Connecticut, 1982). 61–63.

    Google Scholar 

  12. Meyers, D.G., Maloley, P.A. & Weeks, D. Safety of antioxidant vitamins. Arch. Intern. Med. 156, 925–935 (1996).

    Article  CAS  Google Scholar 

  13. Auer, B.L., Auer, D. & Rodgers, A.L. The effect of ascorbic acid ingestion on the biochemical and physicochemical risk factors associated with calcium oxalate kidney stone formation. Clin. Chem. Lab. Med. 36, 143–147 (1998).

    Article  CAS  Google Scholar 

  14. Barness, L.A. Safety considerations with high ascorbic acid dosage. Ann. NY Acad. Sci. 258, 523–528 (1975).

    Article  CAS  Google Scholar 

  15. Dresser, G.K., Spence, J.D. & Bailey, D.G. Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome p450 3A4 inhibition. Clin. Pharmacokinet. 38, 41–57 (2000).

    Article  CAS  Google Scholar 

  16. Anonymous. Grapefruit warning label: now official in some countries. Drugs Ther. Perspect. 12, 12–13 (1998).

  17. Committee on Safety of Medicines, Medicines Control Agency. Terfenadine: now only available on prescription. Curr. Probl. Pharmacovig. 23, 9 (1997).

  18. Committee on Safety of Medicines, Medicines Control Agency. Astemizole (Hismanal): only available on prescription. Curr. Probl. Pharmacovig. 25, 2 (1999).

  19. Bailey, D.G., Spence, J.D., Edgar, B., Bayliff, C.D. & Arnold, J.M. Ethanol enhances the hemodynamic effects of felodipine. Clin. Invest. Med. 12, 357–362 (1989).

    CAS  PubMed  Google Scholar 

  20. Dresser, G.K., Bailey, D.G. & Carruthers, S.G. Grapefruit juice–felodipine interaction in the elderly. Clin. Pharmacol. Ther. 68, 28–34 (2000).

    Article  CAS  Google Scholar 

  21. Dresser, G.K., Spence, J.D. & Bailey, D.G. Pharmacokinetic–pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Clin. Pharmacokinet. 38, 41–57 (2000).

    Article  CAS  Google Scholar 

  22. Bailey, D.G., Malcolm, J., Arnold, O. & Spence, J.D. Grapefruit juice–drug interactions. Br. J. Clin. Pharmacol. 46, 101–110 (1998).

    Article  CAS  Google Scholar 

  23. Eagling, V.A., Profit, L. & Back, D.J. Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br. J. Clin. Pharmacol. 48, 543–552 (1999).

    Article  CAS  Google Scholar 

  24. Guo, L.Q., Fukuda, K., Ohta, T. & Yamazoe, Y. Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity. Drug Metab. Dispos. 28, 766–771 (2000).

    CAS  PubMed  Google Scholar 

  25. Ranganna, S., Govindarajan, V.S. & Ramana, K.V. Citrus fruits—varieties, chemistry, technology, and quality evaluation. Part II. Chemistry, technology, and quality evaluation. Crit. Rev. Food. Sci. Nutr. 18, 313–386 (1983).

    Article  CAS  Google Scholar 

  26. Ranganna, S., Govindarajan, V.S. & Ramana, K.V. Citrus fruits. Part II. Chemistry, technology, and quality evaluation. B. Technology. Crit. Rev. Food Sci. Nutr. 19, 1–98 (1983).

    Article  CAS  Google Scholar 

  27. Shaw, P.E., Moshonas, M.G., Hearn, C.J. & Goodner, K.L. Volatile constituents in fresh and processed juices from grapefruit and new grapefruit hybrids. J. Agric. Food Chem. 48, 2425–2429 (2000).

    Article  CAS  Google Scholar 

  28. Ohnishi, A. et al. Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4. Br. J. Pharmacol. 130, 1369–1377 (2000).

    Article  CAS  Google Scholar 

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Aronson, J. Forbidden fruit. Nat Med 7, 29–30 (2001). https://doi.org/10.1038/83312

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