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News and Views
Nature Medicine 6, 973 - 974 (2000)
doi:10.1038/79661
Ibuprofen, inflammation and Alzheimer disease
Tony Wyss-Coray1 & Lennart Mucke1
- Gladstone Institute of Neurological Disease and Department of Neurology, University of California San Francisco, California 94141
e-mail: lmucke@gladstone.ucsf.edu
Abstract
Mounting evidence suggests that non-steroidal anti-inflammatory drugs may be useful in reducing the risk of Alzheimer disease. After much study, the mechanism by which these drugs reduce the amyloid deposition associated with the disease is still open to speculation.
Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin or ibuprofen are widely used to alleviate fever, pain and inflammation. Because they also inhibit platelet aggregation, NSAIDs are also used to prevent myocardial infarction and stroke.
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