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Listening for hoof beats in heart beats

Disruption of the Sp1-related transcription factor HF-1b leads to alterations in the cardiac conduction system that result in ventricular arrhythmias and sudden death. What does this tell us about how ventricular cardiomyocytes differentiate into the specialized cells that form the heart's conductance system?

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Figure 1: Cardiac conduction system.

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Robbins, J., Dorn, G. Listening for hoof beats in heart beats. Nat Med 6, 968–970 (2000). https://doi.org/10.1038/79652

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