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Commentary
Nature Medicine 6, 852 - 855 (2000)
doi:10.1038/78595
Mice without telomerase: what can they teach us about human cancer?
Steven E. Artandi1 & Ronald A. DePinho2
- Department of Adult Oncology, Dana-Farber Cancer Institute , Boston, Massachusetts 02115
- Departments of Genetics and Medicine, Harvard Medical
School, Boston, Massachusetts 02115
e-mail: ron_depinho@dfci.harvard.edu
Abstract
Unicellular organisms, human cells and mice have provided insights into the processes of senescence, crisis, genomic instability and cancer in humans. Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instability due to telomere dysfunction, and the suppression or promotion of cancer.
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