Nature Medicine
6, 852 - 855 (2000)
doi:10.1038/78595
Mice without telomerase: what can they teach us about human cancer?Steven E. Artandi1
& Ronald A. DePinho21
Department of Adult Oncology, Dana-Farber Cancer Institute
, Boston, Massachusetts 02115
2
Departments of Genetics and Medicine, Harvard Medical
School, Boston, Massachusetts 02115
ron_depinho@dfci.harvard.edu
Unicellular organisms, human cells and mice have provided insights into
the processes of senescence, crisis, genomic instability and cancer in humans.
Here, Artandi and DePinho discuss how studies in mice have uncovered a complex
interplay between the ARF-p53 pathway, genomic instability due to telomere
dysfunction, and the suppression or promotion of cancer.
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