Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology
Woodring E. Wright
& Jerry W. Shay
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039
Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer.
