University of Massachusetts Medical Center Departments of Molecular Genetics and Microbiology and Program in Molecular Medicine 373 Plantation Street Worcester, Massachussetts 01605
Mario.Stevenson@UMASSMED.EDU
Elucidation of the mechanisms behind nuclear translocation of viral nucleic acids will lead to improvements in the design of anti-retroviral drugs and gene therapy vectors that are able to transduce non-dividing cells. A recent study has identified a triple stranded HIV cDNA intermediate of reverse transcription, or a 'central DNA flap,' as a component of HIV nuclear import.
