UCSF Cancer Center, 2340 Sutter Street
, San Francisco, California 94143-0128,
USA
GEvan@cc.ucsf.edu
The proto-oncogene MYCN, a regulator of cell proliferation
and cell death, is amplified in aggressive neuroblastomas, whereas expression
of the apoptotic effector caspase 8 is suppressed. Understanding why this
nervous system tumor should choose to up or down regulate these particular
apoptotic factors may provide important information about oncogenesis and
indicate new strategies for the treatment of neuroblastoma (
pages 529−535).
