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Volume 6 Issue 4, April 2000

Vascular endothelial growth factor (VEGF) and inflammatory agents can cause pathological increases in vascular leakage, leading to edema and swelling, whereas angiopoietin-1 can act reciprocally as an anti-permeability factor. On page 460, Thurston et al. report that acute adenoviral gene delivery of angiopoietin-1 protects adult vasculature from potentially lethal VEGF- and inflammation-induced leakage, without causing vascular morphologic changes. The cover shows the enlargement of skin vessels (in blue) seen after chronic transgenic delivery of angiopoietin-1, which is not seen after acute adenovirus-mediated delivery to the adult.

Volume 6 Issue 4

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Editorial

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Letters to the Editor

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News

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Obituary

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Commentary

  • The most exciting recently developed therapeutic approaches for glioma and other types of nervous system tumors involve combinations of immuno-therapy and neural stem cells. But we must bear in mind that the human brain differs greatly from the mouse brain, and that approaches that are effective in animal models may not always be safe for humans.

    • Mark Noble
    Commentary
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Book Review

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News & Views

  • Many mechanisms have been proposed for the positive effects of monoclonal antibodies in cancer therapy. New data indicate that both the variable, antigen-binding region of an antibody and the Fc region are capable of influencing anti-cancer immunity (pages 443–446).

    • Alan N. Houghton
    • David A. Scheinberg
    News & Views

  • Recent findings indicate that p53 regulates the expression of the tumor suppressor gene maspin, providing new mechanistic information about the factors that negatively regulate tumor cell metastasis.

    • Mary J.C. Hendrix
    News & Views

  • Although Helicobacter pylori affects a large percentage of the population, only a small percentage of carriers develop peptic ulcers and gastric cancer. Recent investigations have begun to identify the factors that lead to these complications.

    • Martin J. Blaser
    News & Views

  • Toxic shock syndrome is caused by bacterial production of exotoxins called superantigens. New therapeutic peptides reduce superantigen toxicity by interfering with the ability of superantigens to induce a cellular immune response, and also serve as potent adjuvants to increase the neutralizing antibody response (pages 414–421 ).

    • Patrick M. Schlievert
    News & Views

  • Ischemic peripheral neuropathy is a frequent, severe and irreversible complication of critical limb ischemia. Therapeutic angiogenesis may ameliorate vascular insufficiency and may also provide direct beneficial effects on neural integrity, indicating a new paradigm for the treatment of neuronal disorders (pages 405–413).

    • Lloyd Paul Aiello
    News & Views

  • Recent research for ways to repair brain and spinal cord injuries has focused on the use of olfactory ensheathing glia to induce neuronal regeneration. However, differences between rat models and men, and difficulties in obtaining large quantities of this cell type indicate that we still are a long way from using this approach in human nervous system repair.

    • Geoffrey Raisman
    News & Views

  • Glutamate receptors are thought to play an essential role in the central nervous system damage that results from certain neurological insults. A recent report indicates that immunization against a glutamate receptor subunit may have neuroprotective effects, but we must consider the potential for pathogenic autoimmune responses.

    • Matthew J.A. Wood
    • Angela Vincent
    News & Views

  • Cleaveage of amyloid precursor protein by β- and γ- secretases is known to yield the peptide amyloid-β, which is suggested to be cytotoxic and has been associated with a number of neurdegenerative diseases. New findings suggest that caspases can also cleave APP to yield other peptides that initiate cell death by unknown mechanisms (pages 397–404 ).

    • Carolanne E. Milligan
    News & Views

    • Kristine Novak
    • Boyana Konforti
    • John MacFarlane
    News & Views
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