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Volume 6 Issue 3, March 2000

The adult brain is known to have neural progenitor and stem cells, although these cells have not been identified in adult humans. On page 271, Roy et al. report the identification and isolation of neural progenitor cells from the adult human hippocampus. The cover shows cultured neurons, derived from dentate gyrus tissue of a 20-year-old man, that express the neural progenitor marker βIII-tubulin (red) along with green fluorescent protein.

Volume 6 Issue 3

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Editorial

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Commentary

  • Malaria is a disease of poor countries. The development of malaria vaccines requires considerable investment, for which there is little commercial interest, particularly for transmission-blocking vaccines that have the public health objective of protecting communities from the spread of malaria rather than protecting individuals from the disease. Here, Carter et al. summarize the report of a committee of experts on the relevance and prospects for these vaccines.

    • Richard Carter
    • Kamini N. Mendis
    • Allan Saul
    Commentary
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Book Review

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News & Views

  • Neuronal progenitor cells, isolated from the adult human dentate gyrus, are capable of proliferating and differentiating in vitro. Further studies into this approach may lead to neuronal transplantation therapies for human neurodegenerative disorders (271–277).

    • Jack P. Antel
    • Josephine Nalbantoglu
    • André Olivier
    News & Views

  • Transplantation of pancreatic islet cells could provide a cure for diabetes. However, it has been difficult to obtain sufficient numbers of purified islets from a single cadaver pancreas. Stem cell technology may someday overcome this limitation, and may also make possible the use of autologous tissues (278–282).

    • David H. Sachs
    • Susan Bonner-Weir
    News & Views

  • Fusions of dendritic cells and renal carcinoma cells have been used as a vaccine in the effective and non-toxic treatment of patients with metastatic renal cancer. This approach may be applicable to other tumor types (pages 332–336).

    • Donald W. Kufe
    News & Views

  • Although past epidemiological studies have supported the theory that there is a genetic component to schizophrenia, the genetic data have been inconsistent. However, an overall analysis indicates several chromosome regions with good candidate genes for schizophrenia susceptibility.

    • Brien Riley
    • Robert Williamson
    News & Views

  • Cannabinoid agonists arrest tumor progression in a rodent model of malignant glioma. Will these molecules provide a starting point for new strategies for anti-cancer therapy (313–319)?

    • Daniele Piomelli
    News & Views

  • Intestinal infections with enteropathogenic Escherichia coli are potentially devastating and difficult to treat. Outbreaks linked to food-borne spread of the bacteria have occurred repeatedly in the US in recent years. New approaches to neutralizing the bacterial toxins responsible for the worst effects of the disease may provide lifesaving tools for clinicians (265–270 ).

    • John J. Donnelly
    • Rino Rappuoli
    News & Views

  • The discovery of ‘new variant’ Creutzfeldt-Jakob disease (vCJD) was announced in March 1996. By mid-1997, several lines of evidence linked vCJD with bovine spongiform encephalopathy (BSE), the most compelling being that BSE and vCJD produced an identical disease in conventional mice. Recent studies in transgenic mice support this conclusion.

    • Moira E. Bruce
    News & Views

  • Negative selection of developing T cells in the thymus is not the only mechanism by which central tolerance to self antigens is acquired. Alternative possibilities are demonstrated in a new model of autoimmune disease (pages 298–305).

    • Syamal K. Datta
    News & Views

  • The incomplete distribution of HIV therapy, coupled with uneven HIV transmission rates throughout a population, seem to predict a failure of commodity health care to reduce HIV incidence. Paradoxically, heterogeneity in HIV transmission risk combined with the appropriately targeted antiretroviral therapeutic strategy may offer a substantial public health benefit if HIV surveillance and treatment can be coordinated.

    • G.P. Garnett
    • L.M. Bartley
    • R.M. Anderson
    News & Views

    • Sandra Aamodt
    • Karen Birmingham
    • Kristine Novak
    News & Views
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