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Nature Medicine 6, 259 - 261 (2000)
doi:10.1038/73101
Positive selection for autoimmunity
Syamal K. Datta1
- Departments of Medicine (Rheumatology Division) and
Microbiology-Immunology, Northwestern Universtiy Medical School,
Chicago, Illinois 60611, USA.
e-mail: skd257@nwu.edu
Abstract
Negative selection of developing T cells in the thymus is not the only mechanism by which central tolerance to self antigens is acquired. Alternative possibilities are demonstrated in a new model of autoimmune disease (pages 298–305).
Autoimmunity is prevented by central and peripheral tolerance mechanisms. T cells developing centrally (in the thymus) that happen to generate high-affinity receptors for self-peptides are negatively selected or deleted, provided the peptides are adequately presented there.
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