 | Figure 1
Nature Medicine
6, 313 - 319 (2000)
doi:10.1038/73171
Anti-tumoral action of cannabinoids: Involvement of sustained ceramide
accumulation and extracellular signal-regulated kinase activationIsmael Galve-Roperh, Cristina Sánchez, María Luisa Cortés, Teresa Gómez del Pulgar, Marta Izquierdo
& Manuel Guzmán | | | | Figure 1. Cannabinoid-induced regression of malignant gliomas in Wistar rats.
a, Kaplan-Meier survival curves of rats with brain tumors. Tumors
were induced in 45 rats by intracerebral injection of C6 glioma cells (day
0); 15 rats were left untreated (---), 15 were treated with THC (—)
and 15 were treated with WIN-55,212-2 ( ) between
days 12 and 19. Tumor-bearing rats treated with THC or WIN-55,212-2 lived
significantly longer than those in the control group (P
< 0.01). THC and WIN-55,212-2 were also given to rats (
n = 5 for each) in which no tumor was induced (--).
b, Gadolinium-enhanced magnetic resonance views in axial (upper) and
coronal (lower) projections of a rat brain before (left) and after (right)
THC treatment. A 100-mm3 glioma (arrows) was completely eradicated
by treatment with 500  g THC. The image was obtained 7 days after THC delivery
ended. c, Absence of apoptosis in the subventricular zone of rat brain
after treatment with THC or WIN-55,212-2 for 7 d. The lateral ventricle of
the right cerebral hemisphere (of cannabinoid inoculation) is flanked by the
lateral septal nucleus (left) and the caudate putamen (right). The labeling
in control rat (top) shows basal apoptosis in the caudate putamen. Data represent
results obtained in two other rats of each type.
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