Departments of Medicine (Rheumatology Division) and
Microbiology-Immunology, Northwestern Universtiy Medical School,
Chicago, Illinois 60611, USA.
skd257@nwu.edu
Negative selection of developing T cells in the thymus is not the
only mechanism by which central tolerance to self antigens is acquired. Alternative
possibilities are demonstrated in a new model of autoimmune disease (pages
298−305).
