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| Editorial |  Top |
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The changing face of biomedical research? p113
doi:10.1038/72160
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(73K)
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| Letters to Editor | Top |
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Thromboembolic complications after treatment with monoclonal antibody
against CD40 ligand p114
Tatsuo Kawai, David Andrews, Robert B. Colvin, David H. Sachs
& A. Benedict Cosimi
doi:10.1038/72162
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Reply to Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand p114
Allan D. Kirk
& David M. Harlan
doi:10.1038/72164
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(84K)
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Failure of combined costimulatory blockade in animal transplant model p115
Vikas R Dharnidharka, Kenneth Schowengerdt
& Suzanne Skoda-Smith
doi:10.1038/72166
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Reply to Failure of combined costimulatory blockade in animal transplant model p115
Yongsheng Li
& Terry B. Strom
doi:10.1038/72168
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(85K)
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Rod photoreceptor rescue or degeneration p116
Deepak P. Edward
& Mark O.M. Tso
doi:10.1038/72170
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(137K)
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Reply to Rod photoreceptor rescue or degeneration p116
Serge Picaud
& José Sahel
doi:10.1038/72172
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(137K)
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Celera: financial optimism, scientific skepticism p116
David Dickson
doi:10.1038/72174
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(137K)
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| News | Top |
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UN acknowledges HIV/AIDS as a threat to world peace p117
Karen Birmingham
doi:10.1038/72177
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(142K)
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Biotechnology industry responds to gene therapy death p118
Helen Commander
doi:10.1038/72181
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Activists threaten academic research funding p119
Kristine Novak
doi:10.1038/72184
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(153K)
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Sanctions programs expand despite failure to increase vaccination p119
Alan Dove
doi:10.1038/72186
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(153K)
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Australian universities told to commercialize p120
Rada Rouse
doi:10.1038/72189
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(134K)
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University of Arizona misconduct investigation ruled improper p120
Tinker Ready
doi:10.1038/72191
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Business group presses for broader release of scientific data p121
Alan Dove
doi:10.1038/72194
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(98K)
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Insurers agree to cover cancer trial costs voluntarily p121
Alicia Ault
doi:10.1038/72196
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(98K)
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From biotech to bank robbery p121
Tinker Ready
doi:10.1038/72198
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| Commentary | Top |
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Vaccines and the induction of functional antibodies: Time to look beyond
the molecules of natural infection? pp123 - 125
Dennis R. Burton
& Paul W.H.I. Parren
doi:10.1038/72200
Abstract | Full text | PDF
(102K)
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| Book Review | Top |
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A New Interpretation of the New England Witch Trials p127
Reviewed by: R. Martyn Bracewell
doi:10.1038/72203
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(108K)
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| News and Views | Top |
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IgG surfaces as an important component in mucosal protection pp129 - 130
Marjorie Robert-Guroff
doi:10.1038/72206
Abstract | Full text | PDF
(212K)
See also: Article by Baba et al. | Article by Mascola et al. |
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Gut reaction p130
Sandra Aamodt
doi:10.1038/72209
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(132K)
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Leaky vessels? Call Ang1! pp131 - 132
Rakesh K. Jain
& Lance L. Munn
doi:10.1038/72212
Abstract | Full text | PDF
(333K)
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Does Alzheimer disease tilt the scales of amyloid degradation versus
accumulation? pp133 - 134
Charles Glabe
doi:10.1038/72215
Abstract | Full text | PDF
(112K)
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New feelings about the role of sensory nerves in inflammation pp134 - 135
Susan D. Brain
doi:10.1038/72218
Abstract | Full text | PDF
(225K)
See also: Article by Steinhoff et al. |
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The envelope, please: Nuclear lamins and disease pp136 - 137
Robert A. Hegele
doi:10.1038/72221
Abstract | Full text | PDF
(119K)
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Cyclopentenone prostaglandins—new allies in the war on inflammation pp137 - 138
Derek A. Willoughby, Adrian R. Moore
& Paul R. Colville-Nash
doi:10.1038/72224
Abstract | Full text | PDF
(109K)
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The first steps on the gene therapy pathway to anti-sickling success
pp139 - 140
Stefan Karlsson
doi:10.1038/72227
Abstract | Full text | PDF
(202K)
See also: Article by Blouin et al. |
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MIF mediation of sepsis pp140 - 141
Thomas R. Martin
doi:10.1038/72230
Abstract | Full text | PDF
(164K)
See also: Article by Calandra et al. |
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Oral examination p141
Kristine Novak
doi:10.1038/72232
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(154K)
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Research news p142
Kristine Novak
& John MacFarlane
doi:10.1038/72235
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(97K)
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| Articles | Top |
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Identification of the major A 1−42-degrading catabolic
pathway in brain parenchyma: Suppression leads to biochemical and pathological
deposition pp143 - 150
Nobuhisa Iwata, Satoshi Tsubuki, Yoshie Takaki, Kaori Watanabe, Misaki Sekiguchi, Emi Hosoki, Maho Kawashima-Morishima, Hahn-Jun Lee, Emi Hama, Yoko Sekine-Aizawa
& Takaomi C. Saido
doi:10.1038/72237
Abstract | Full text | PDF
(461K)
See also: News and Views by Glabe |
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Agonists of proteinase-activated receptor 2 induce inflammation by a
neurogenic mechanism pp151 - 158
M. Steinhoff, N. Vergnolle, S.H. Young, M. Tognetto, S. Amadesi, H.S. Ennes, M. Trevisani, M.D. Hollenberg, J.L. Wallace, G.H. Caughey, S.E. Mitchell, L.M. Williams, P. Geppetti, E.A. Mayer
& N.W. Bunnett
doi:10.1038/72247
Abstract | Full text | PDF
(768K)
See also: News and Views by Brain |
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Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke pp159 - 163
Geoffrey T. Manley, Miki Fujimura, Tonghui Ma, Nobuo Noshita, Ferda Filiz, Andrew W. Bollen, Pak Chan
& A.S. Verkman
doi:10.1038/72256
Abstract | Full text | PDF
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Protection from septic shock by neutralization of macrophage migration
inhibitory factor pp164 - 170
Thierry Calandra, Bernd Echtenacher, Didier Le Roy, Jérôme Pugin, Christine N. Metz, Lothar Hültner, Didier Heumann, Daniela Männel, Richard Bucala
& Michel P. Glauser
doi:10.1038/72262
Abstract | Full text | PDF
(169K)
See also: News and Views by Martin |
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The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development pp171 - 176
Dimitrios Balomenos, Juan Martín-Caballero, Maria I. García, Ignacio Prieto, Juana M. Flores, Manuel Serrano
& Carlos Martínez-A
doi:10.1038/72272
Abstract | Full text | PDF
(338K)
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Genetic correction of sickle cell disease: Insights using transgenic
mouse models pp177 - 182
Marie-José Blouin, Hugues Beauchemin, Adrian Wright, Monique De Paepe, Martin Sorette, Anne-Marie Bleau, Betty Nakamoto, Ching-Nan Ou, Georges Stamatoyannopoulos
& Marie Trudel
doi:10.1038/72279
Abstract | Full text | PDF
(340K)
See also: News and Views by Karlsson |
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Myosin light chain kinase mediates sarcomere organization during cardiac
hypertrophy in vitro pp183 - 188
Hiroki Aoki, Junichi Sadoshima
& Seigo Izumo
doi:10.1038/72287
Abstract | Full text | PDF
(554K)
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The Ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis pp189 - 195
Xiangming Xing, Shao-Chun Wang, Weiya Xia, Yiyu Zou, Ruping Shao, Ka Yin Kwong, Zhenming Yu, Su Zhang, Susan Miller, Leaf Huang
& Mien-Chie Hung
doi:10.1038/72294
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Maspin is an angiogenesis inhibitor pp196 - 199
Ming Zhang, Olga Volpert, Yihui H. Shi
& Noël Bouck
doi:10.1038/72303
Abstract | Full text | PDF
(469K)
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Human neutralizing monoclonal antibodies of the IgG1 subtype protect
against mucosal simian−human immunodeficiency virus infection pp200 - 206
Timothy W. Baba, Vladimir Liska, Regina Hofmann-Lehmann, Josef Vlasak, Weidong Xu, Seyoum Ayehunie, Lisa A. Cavacini, Marshall R. Posner, Hermann Katinger, Gabriela Stiegler, Bruce J. Bernacky, Tahir A. Rizvi, Russell Schmidt, Lori R. Hill, Michale E. Keeling, Yichen Lu, Joel E. Wright, Ting-Chao Chou
& Ruth M. Ruprecht
doi:10.1038/72309
Abstract | Full text | PDF
(268K)
See also: News and Views by Robert-Guroff | Article by Mascola et al. |
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Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV
chimeric virus by passive infusion of neutralizing antibodies pp207 - 210
John R. Mascola, Gabriela Stiegler, Thomas C. VanCott, Hermann Katinger, Calvin B. Carpenter, Chris E. Hanson, Holly Beary, Deborah Hayes, Sarah S. Frankel, Deborah L. Birx
& Mark G. Lewis
doi:10.1038/72318
Abstract | Full text | PDF
(125K)
See also: News and Views by Robert-Guroff | Article by Baba et al. |
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Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population pp211 - 214
David E. Anderson, Katarzyna D. Bieganowska, Amit Bar-Or, Enedina M.L. Oliveira, Beatriz Carreno, Mary Collins
& David A. Hafler
doi:10.1038/72323
Abstract | Full text | PDF
(135K)
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Molecular mimicry mediated by MHC class Ib molecules after infection with Gram-negative pathogens pp215 - 218
Wei-Feng Lo, Amina S. Woods, Amy DeCloux, Robert J. Cotter, Eleanor S. Metcalf
& Mark J. Soloski
doi:10.1038/72329
Abstract | Full text | PDF
(153K)
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Directed vascular expression of the thromboxane A2 receptor results in intrauterine growth retardation pp219 - 221
Bianca Rocca, Alex L. Loeb, Jerome F. Strauss III, Roberta Vezza, Aida Habib, Hongwei Li
& Garret A. FitzGerald
doi:10.1038/72334
Abstract | Full text | PDF
(259K)
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| New Technology | Top |
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Recombinant lipid-tagged antibody fragments as functional cell-surface
receptors pp223 - 227
John de Kruif, Marella Tijmensen, Joel Goldsein
& Ton Logtenberg
doi:10.1038/72339
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(230K)
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On the market p228
doi:10.1038/72347
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(171K)
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| Erratum | Top |
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Erratum p229
doi:10.1038/72353
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(78K)
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