Cyclopentenone prostaglandinsnew allies in the war on inflammation
Derek A. Willoughby, Adrian R. Moore
& Paul R. Colville-Nash
Department of Experimental Pathology, St. Bartholomew's & Royal London School of Medicine & Dentistry Charterhouse Square London EC1M 6BQ. UK
p.r.colville-nash@mds.qmw.ac.uk
Although the effects of anti-inflammatory drugs have been well studied, little is known about the signaling pathways involved in the inflammatory response. The recent finding that cyclopentenone prostaglandins inhibit IB kinase provides a new explanation for the anti-inflammatory effects of these molecules.