New feelings about the role of sensory nerves in inflammation
Susan D. Brain
Centre for Cardiovascular Biology & Medicine, New
Hunt's House, GKT School of Biomedical Sciences, King's College,
Guy's Campus, London SE1 1UL, UK
sue.brain@kcl.ac.uk
The pro-inflammatory agents trypsin and mast cell tryptase cleave and activate
proteinase-activated receptor 2 (PAR2), which is expressed on sensory nerves,
explaining a previously unknown mechanism in neurogenic inflammation (151−158).