Peter J. Ratcliffe, Christopher W. Pugh
& Patrick H. Maxwell
The Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK
peter.ratcliffe@imm.ox.ac.uk
Hypoxia-inducible factor (HIF) is a key transcriptional regulator of the cellular response to hypoxia that is upregulated in many common cancers. Blockade of the pathway may provide a new opportunity for the development of cancer therapeutics (pages 1335-1340).
