Cholesterol esters and atherosclerosis−a game of ACAT and mouse
Lawrence L. Rudel
& Gregory S. Shelness
Arteriosclerosis Research Program, Department of Pathology Wake Forest University School of Medicine 300 South Hawthorne Road Winston-Salem, NC 27103 USA
lrudel@wfubmc.edu
Disruption of the gene encoding the cholesterol modifying enzyme ACAT2 in mice leads to a reduced capacity to absorb cholesterol and resistance to diet-induced hypercholesterolemia. This suggests that ACAT2 may be a good target for prevention of atherosclerosis. (pages 1341−1347)
