Nature Medicine
6, 1221 - 1227 (2000)
doi:10.1038/81321
Decoding calcium signals involved in cardiac growth and functionNorbert Frey, Timothy A. McKinsey
& Eric N. Olson
Department of Molecular Biology, The University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390-9148,
USA
Correspondence should be addressed to Eric N. Olson eolson@hamon.swmed.eduCalcium is central in the regulation of cardiac contractility, growth and gene expression. Variations in the amplitude, frequency and compartmentalization of calcium signals are decoded by calcium/calmodulin-dependent enzymes, ion channels and transcription factors. Understanding the circuitry for calcium signaling creates opportunities for pharmacological modification of cardiac function.
|
