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Article
Nature Medicine 6, 1160 - 1166 (2000)
doi:10.1038/80506
Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine
Yu-quan Wei1, Qing-ru Wang1, Xia Zhao2, Li Yang1, Ling Tian1, You Lu1, Bin Kang1, Chong-jiu Lu1, Mei-juan Huang1, Yan-yan Lou1, Fei Xiao1, Qiu-ming He1, Jing-mei Shu1, Xing-jiang Xie1, Yun-qiu Mao1, Shong Lei1, Feng Luo1, Li-qun Zhou1, Chong-en Liu1, Hao Zhou1, Yu Jiang1, Feng Peng1, Liang-ping Yuan1, Qiu Li1, Yang Wu1 & Ji-yan Liu1
Abstract
The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer therapy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for the anti-tumor activity. These observations may provide a new vaccine strategy for cancer therapy through the induction of an autoimmune response against the tumor endothelium in a cross-reaction.
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