Nature Medicine
6, 1147 - 1153 (2000)
doi:10.1038/80489
Secretory leukocyte protease inhibitor mediates non-redundant functions
necessary for normal wound healingGillian S. Ashcroft1, 3, Kejian Lei1, 3, Wenwen Jin1, Glenn Longenecker2, Ashok B. Kulkarni2, Teresa Greenwell-Wild1, Hollie Hale-Donze1, George McGrady1, Xiao-Yu Song1
& Sharon M. Wahl11
Oral Infection and Immunity Branch, National Institute
of Dental & Craniofacial Research, Building 30, 30 Convent
Drive, MSC 4352, National Institutes of Health,
Bethesda, Maryland 20892, USA
2
Gene Targeting Facility, National Institute of Dental
& Craniofacial Research, Building 30, 30 Convent Drive,
MSC 4352, National Institutes of Health, Bethesda
, Maryland 20892, USA
3
G.A. & K.L. contributed equally to this study.
Correspondence should be addressed to Sharon M. Wahl smwahl@dir.nidcr.nih.govSecretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor
with anti-microbial properties found in mucosal fluids. It is expressed during
cutaneous wound healing. Impaired healing states are characterized by excessive
proteolysis and often bacterial infection, leading to the hypothesis that
SLPI may have a role in this process. We have generated mice null for the
gene encoding SLPI (Slpi), which show impaired cutaneous wound healing
with increased inflammation and elastase activity. The altered inflammatory
profile involves enhanced activation of local TGF- in Slpi-null
mice. We propose that SLPI is a pivotal endogenous factor necessary for optimal
wound healing.
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