VEGF gene therapy: stimulating angiogenesis or angioma-genesis?
Peter Carmeliet
Center for Transgene Technology & Gene Therapy KU Leuven, Campus Gasthuisberg Herestraat 49 B-3000 Leuven Belgium
peter.carmeliet@med.kuleuven.ac.be
The finding that unregulated, continuous delivery of vascular endothelial growth factor to the myocardium causes the formation of hemangiomas and death in mice indicates that more research is required on this potent molecule before clinical trials can proceed.
