Breaking up receptor alliances: the parting of CD3 and CD4
Abraham Kupfer
Division of Cell Biology Dept. of Pediatrics National Jewish Medical and Research Center 1400 Jackson St. Denver, Colorado USA 80206
kupfera@njc.org
The T-cell co-receptor CD4 is required for T-cell activation, and it may be involved in stabilization of the T-cell receptor and class II major histocompatibility complexes during antigen presentation. However, video microscopic analyses of the interactions between T cells and antigen-presenting cells indicate otherwise.
