Harvard Medical School, Department of Pathology and Center for Cancer Biology 200 Longwood Avenue, Armenise Building D2/544A, Boston, Massachusetts 02115-5701, USA
karl_munger@hms.harvard.edu
Kaposi sarcoma-associated herpesvirus (KSHV) is linked to the development of Kaposi sarcoma and certain lymphoproliferative malignancies. The main immunogenic latent nuclear antigen of KSHV can form a complex with retinoblastoma tumor suppressor protein and transform cells, indicating that the oncogenic activities of KSHV are mechanistically related to the transforming functions of the small DNA tumor viruses (pages 1121−1127).
