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TY  - JOUR

AU  - Mundy, G.

TI  - Stimulation of bone formation in vitro and in rodents by statins

JO  - Science

PY  - 1999///

VL  - 286

SP  - 1946

EP  - 1949

M3  - 10.1126/science.286.5446.1946

N1  - 10.1126/science.286.5446.1946

UR  - http://dx.doi.org/10.1126/science.286.5446.1946

ER  - 



TY  - JOUR

AU  - Alberts, A.W.

TI  - Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

JO  - Proc. Natl. Acad. Sci. USA

PY  - 1980///

VL  - 77

SP  - 3957

EP  - 3961

ER  - 



TY  - JOUR

AU  - Hamelin, B.A.

AU  - Turgeon, J.

TI  - Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors

JO  - Trends Pharmacol. Sci.

PY  - 1998///

VL  - 19

SP  - 26

EP  - 37

M3  - 10.1016/S0165-6147(97)01147-4

N1  - 10.1016/S0165-6147(97)01147-4

UR  - http://dx.doi.org/10.1016/S0165-6147(97)01147-4

ER  - 



TY  - JOUR

AU  - Zhang, F.L.

AU  - Casey, P.J.

TI  - Protein prenylation: molecular mechanisms and functional consequences

JO  - Ann. Rev. Biochem.

PY  - 1996///

VL  - 65

SP  - 241

EP  - 269

M3  - 10.1146/annurev.biochem.65.1.241

N1  - 10.1146/annurev.biochem.65.1.241

UR  - http://dx.doi.org/10.1146/annurev.biochem.65.1.241

ER  - 



TY  - JOUR

AU  - Garrett, I.R.

AU  - Escobedo, A.

AU  - Mundy, G.R.

TI  - N2-containing bisphosphonates risedronate and ibandronate stimulate bone formation in organ culture

JO  - J. Bone Miner. Res.

PY  - 1999///

VL  - 14

SP  - 

EP  - 

ER  - 



TY  - JOUR

AU  - Luckman, S.P.

TI  - J. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras

JO  - J. Bone Miner. Res.

PY  - 1998///

VL  - 13

SP  - 58

EP  - 589

ER  - 



TY  - JOUR

AU  - Fisher, J.E.

TI  - Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption and kinase activation in vitro

JO  - Proc. Natl. Acad. Sci. USA

PY  - 1999///

VL  - 96

SP  - 133

EP  - 138

M3  - 10.1073/pnas.96.1.133

N1  - 10.1073/pnas.96.1.133

UR  - http://dx.doi.org/10.1073/pnas.96.1.133

ER  - 



TY  - JOUR

AU  - van Beek, E.

TI  - Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates

JO  - Biochem. Biophys. Res. Commun.

PY  - 1999///

VL  - 264

SP  - 108

EP  - 111

M3  - 10.1006/bbrc.1999.1499

N1  - 10.1006/bbrc.1999.1499

UR  - http://dx.doi.org/10.1006/bbrc.1999.1499

ER  - 



TY  - JOUR

AU  - Plotkin, L.I.

TI  - Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin

JO  - J. Clin. Invest.

PY  - 1999///

VL  - 104

SP  - 1363

EP  - 1374

ER  - 



TY  - JOUR

AU  - Bauer, D.C.

TI  - Statin use, bone mass and fracture: an analysis of two prospective studies

JO  - J. Bone Miner. Res.

PY  - 1999///

VL  - 14

SP  - 

EP  - 

ER  -