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| Editorial |  Top |
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Gene therapy—a loss of innocence p1
doi:10.1038/71427
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(73K)
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| Letters to Editor | Top |
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Revisiting calcineurin and human heart failure pp2 - 3
Lana Tsao, Craig Neville, Antonio Musaro, Karl J.A. McCullagh
& Nadia Rosenthal
doi:10.1038/71478
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(200K)
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Reply to Revisiting calcineurin and human heart failure p3
Hae W. Lim
& Jeffery D. Molkentin
doi:10.1038/71511
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(86K)
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HLA types in South Africa p3
John S. Sullivan
doi:10.1038/71513
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(86K)
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Adenovirus E1A and Ewing tumors p4
E. de Alava, R. Sanchez-Prieto
& S. Ramon y Cajal
doi:10.1038/71515
Abstract | Full text | PDF
(87K)
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| News | Top |
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China's first international HIV vaccine meeting: The war of the roses
p5
Myrna Watanabe
doi:10.1038/71535
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(294K)
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Researchers and regulators reflect on first gene therapy death p6
Tom Hollon
doi:10.1038/71545
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(101K)
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Bioengineering and phytomedicines among FY00 congressional priorities
p7
Karen Birmingham
doi:10.1038/71560
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(125K)
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Research data access bill issued p8
Alan Dove
doi:10.1038/71588
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(121K)
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Cancer research director steps down after 17 years p8
Kristine Novak
doi:10.1038/71590
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(121K)
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Canada ushers in new era in health research p8
Brian Hoyle
doi:10.1038/71593
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(121K)
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New bill mandates sanctuary system for retired chimps p9
Alan Dove
doi:10.1038/71605
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(108K)
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Israeli research must be re-directed p9
Haim Watzman
doi:10.1038/71607
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(108K)
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Italian government reneges on research promises p9
Martina Ballmaier
doi:10.1038/71610
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(108K)
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Opposition to new marijuana research rules p10
Marlene Cimons
doi:10.1038/71446
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(91K)
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Survey shows Australian scientists' discontent p10
Rada Rouse
doi:10.1038/71448
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(91K)
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UKXIRA delays potential xenotransplant trial approvals p10
Karen Birmingham
doi:10.1038/71450
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(91K)
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| Book Reviews | Top |
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Genome: The Autobiography of a Species in 23 Chapters p11
Reviewed by: J. Craig Venter
doi:10.1038/71457
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(111K)
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Of Mice, Men, and Microbes—Hantavirus pp11 - 12
Reviewed by: James N. Mills
doi:10.1038/71460
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(174K)
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Flu: The Story of the Great Influenza Pandemic of 1918
and the Search for the Virus that Caused It pp12 - 13
Reviewed by: Nicholas P. Restifo
doi:10.1038/71463
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(190K)
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| News and Views | Top |
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Multiple approaches to multiple sclerosis pp15 - 16
Lawrence Steinman
doi:10.1038/71466
Abstract | Full text | PDF
(143K)
See also: Article by Klein et al. | Article by Pitt et al. | Article by Smith et al. |
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Germ cell transplantation—a fertile field pp16 - 17
Howard J. Cooke
& Philippa T.K. Saunders
doi:10.1038/71469
Abstract | Full text | PDF
(132K)
See also: Article by Ogawa et al. |
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Winning the battle of graft versus host pp18 - 19
Paul J. Martin
doi:10.1038/71472
Abstract | Full text | PDF
(269K)
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A new match-maker p19
Michael Ronemus
doi:10.1038/71475
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(255K)
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Seeing what Alzheimer saw—with magnetic resonance microscopy pp20 - 21
N.C. Fox
& M.N. Rossor
doi:10.1038/71481
Abstract | Full text | PDF
(396K)
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Statins: lower lipids and better bones? pp21 - 23
M.J. Rogers
doi:10.1038/71484
Abstract | Full text | PDF
(386K)
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Sex and the genetic diversity of HIV-1 pp23 - 25
Stuart C. Ray
& Thomas C. Quinn
doi:10.1038/71487
Abstract | Full text | PDF
(130K)
See also: Article by Michelle Long et al. |
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Sticky sugars attract malaria to the fetus pp25 - 26
Mats Wahlgren
& Dorothe Spillmann
doi:10.1038/71490
Abstract | Full text | PDF
(133K)
See also: Article by Beeson et al. |
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Research news p27
Sara Mariani,
Karen Birmingham
& Kristine
Novak
doi:10.1038/71493
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(166K)
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| Articles | Top |
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Transplantation of male germ line stem cells restores fertility in infertile
mice pp29 - 34
Takehiko Ogawa, Ina Dobrinski, Mary R. Avarbock
& Ralph L. Brinster
doi:10.1038/71496
Abstract | Full text | PDF
(804K)
See also: News and Views by Cooke & Saunders |
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A RhoA-derived peptide inhibits syncytium formation induced by respiratory
syncytial virus and parainfluenza virus type 3 pp35 - 40
Manoj K. Pastey, Tara L. Gower, Paul W. Spearman, James E. Crowe Jr.
& Barney S. Graham
doi:10.1038/71503
Abstract | Full text | PDF
(549K)
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Signals leading to apoptosis-dependent inhibition of neovascularization
by thrombospondin-1 pp41 - 48
Benilde Jiménez, Olga V. Volpert, Susan E. Crawford, Maria Febbraio, Roy L. Silverstein
& Noël Bouck
doi:10.1038/71517
Abstract | Full text | PDF
(506K)
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PR39, a peptide regulator of angiogenesis pp49 - 55
Jian Li, Mark Post, Rudiger Volk, Youhe Gao, Min Li, Caroline Metais, Kaori Sato, Jo Tsai, William Aird, Robert D. Rosenberg, Thomas G. Hampton, Jianyi Li, Frank Sellke, Peter Carmeliet
& Michael Simons
doi:10.1038/71527
Abstract | Full text | PDF
(601K)
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Shaping of the autoreactive T-cell repertoire by a splice variant of
self protein expressed in thymic epithelial cells pp56 - 61
Ludger Klein, Matthias Klugmann, Klaus-Armin Nave, V K Tuohy
& Bruno Kyewski
doi:10.1038/71540
Abstract | Full text | PDF
(212K)
See also: News and Views by Steinman |
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Autoimmune encephalomyelitis ameliorated by AMPA antagonists pp62 - 66
Terence Smith, Anthony Groom, Bin Zhu
& Lechoslaw Turski
doi:10.1038/71548
Abstract | Full text | PDF
(724K)
See also: News and Views by Steinman |
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Glutamate excitotoxicity in a model of multiple sclerosis pp67 - 70
David Pitt, Peter Werner
& Cedric S. Raine
doi:10.1038/71555
Abstract | Full text | PDF
(322K)
See also: News and Views by Steinman |
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Gender differences in HIV-1 diversity at time of infection pp71 - 75
E. Michelle Long, Harold L. Martin Jr., Joan K. Kreiss, Stephanie M.J. Rainwater, Ludo Lavreys, Denis J. Jackson, Joel Rakwar, Kishorchandra Mandaliya
& Julie Overbaugh
doi:10.1038/71563
Abstract | Full text | PDF
(213K)
See also: News and Views by Ray & Quinn |
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Persistence of episomal HIV-1 infection intermediates in patients on
highly active anti-retroviral therapy pp76 - 81
Mark E. Sharkey, Ian Teo, Thomas Greenough, Natalia Sharova, Katherine Luzuriaga, John L. Sullivan, R. Pat Bucy, Leondios G. Kostrikis, Ashley Haase, Claire Veryard, Raul E. Davaro, Sarah H. Cheeseman, Jennifer S. Daly, Carol Bova, Richard T. Ellison III, Brian Mady, Kwan Kew Lai, Graeme Moyle, Mark Nelson, Brian Gazzard, Sunil Shaunak
& Mario Stevenson
doi:10.1038/71569
Abstract | Full text | PDF
(195K)
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The decay of the latent reservoir of replication-competent HIV-1 is inversely
correlated with the extent of residual viral replication during prolonged
anti-retroviral therapy pp82 - 85
Bharat Ramratnam, John E. Mittler, Linqi Zhang, Daniel Boden, Arlene Hurley, Fang Fang, Catherine A. Macken, Alan S. Perelson, Martin Markowitz
& David D. Ho
doi:10.1038/71577
Abstract | Full text | PDF
(130K)
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Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic
acid in placental malaria pp86 - 90
James G. Beeson, Stephen J. Rogerson, Brian M. Cooke, John C. Reeder, Wengang Chai, Alexander M. Lawson, Malcolm E. Molyneux
& Graham V. Brown
doi:10.1038/71582
Abstract | Full text | PDF
(138K)
See also: News and Views by Wahlgren & Spillmann |
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Functional conservation of the malaria vaccine antigen MSP-119across
distantly related Plasmodium species pp91 - 95
Rebecca A. O'Donnell, Allan Saul, Alan F. Cowman
& Brendan S. Crabb
doi:10.1038/71595
Abstract | Full text | PDF
(243K)
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Reduced stability of retinoblastoma protein by gankyrin, an oncogenic
ankyrin-repeat protein overexpressed in hepatomas pp96 - 99
Hiroaki Higashitsuji, Katsuhiko Itoh, Toshikazu Nagao, Simon Dawson, Kohsuke Nonoguchi, Tsuneo Kido, R. John Mayer, Shigeki Arii
& Jun Fujita
doi:10.1038/71600
Abstract | Full text | PDF
(231K)
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Intravascular origin of metastasis from the proliferation of endothelium-attached
tumor cells: a new model for metastasis pp100 - 102
A.B. Al-Mehdi, K. Tozawa, A.B. Fisher, L. Shientag, A. Lee
& R.J. Muschel
doi:10.1038/71429
Abstract | Full text | PDF
(352K)
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| New Technology | Top |
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Generation of primary antigen-specific human T- and B-cell responses
in immunocompetent SCID-hu mice pp103 - 106
José M. Carballido, Reiko Namikawa, Nicole Carballido-Perrig, Svetlana Antonenko, Maria-Grazia Roncarolo
& Jan E. de Vries
doi:10.1038/71434
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(4,645K)
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High-sensitivity immunofluorescence for detection of the pro- and anti-inflammatory
cytokines gamma interferon and interleukin-10 on the surface of cytokine-secreting
cells pp107 - 110
Alexander Scheffold, Mario Assenmacher, Luzie Reiners-Schramm, Roland Lauster
& Andreas Radbruch
doi:10.1038/71441
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(163K)
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On the market p111
doi:10.1038/71452
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(588K)
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