Nature Medicine
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September 1999 - Vol 5 No 9
Nature Medicine 5 (1999)
Cover image detail
One of the goals of cancer therapeutic strategies is to inhibit angiogenesis through selective targeting of angiogenic endothelial cells. On page 1032, Ellerby et al. describe new dualfunction peptides designed to target cells in the tumor vasculature and disrupt their mitochondrial membranes. The authors show that these peptides are selectively toxic to endothelial cells undergoing angiogenesis and also have anti-tumor activity in vivo. The cover photograph shows the human dermal microvessel cells that are targeted by the pro-apoptotic peptide.
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