Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS/INSERM/ULP), 1, rue Laurent Fries BP 163, 67400 Illkirch, C.U. de Strasbourg, France cbdm@igbmc.u-strasbg.fr
Although CD4+ and CD8+ T cells are known
to be involved in autoimmune diabetes, their exact mechanism is unknown. Wong
et al. identify the insulin B chain as the antigen recognized by autoimmune
CD8+ T cells capable of inducing diabetes (pages 1026−1031).