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Nature Medicine  5, 992 - 993 (1999)
doi:10.1038/12428

Spotting a killer's target in autoimmune diabetes

Christophe Benoist & Diane Mathis

Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS/INSERM/ULP), 1, rue Laurent Fries BP 163, 67400 Illkirch, C.U. de Strasbourg, France
cbdm@igbmc.u-strasbg.fr

Although CD4+ and CD8+ T cells are known to be involved in autoimmune diabetes, their exact mechanism is unknown. Wong et al. identify the insulin B chain as the antigen recognized by autoimmune CD8+ T cells capable of inducing diabetes (pages 1026−1031).

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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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