Nature Medicine
5, 930 - 937 (1999)
doi:10.1038/11375
Induction of antigen-specific immunosuppression by CD95L cDNA-transfected
'killer' dendritic cellsHiroyuki Matsue1, Keiko Matsue1, Michael Walters1, Ko Okumura2, 3, Hideo Yagita2, 3
& Akira Takashima11
Department of Dermatology, University of Texas Southwestern
Medical Center, 5323 Harry Hines Blvd, Dallas,
Texas 75235-9069, USA
2
Department of Immunology, Juntendo University School
of Medicine, 2-1-1 Hongo, Bunkyo-ku,
Tokyo 113, Japan
3
CREST Japan Science and Technology,Corporation,
Chiyoda-ku, Tokyo 101, Japan
Correspondence should be addressed to Hiroyuki Matsue Dendritic cells (DCs) are special subsets of antigen-presenting cells characterized
by their highly potent capacity to activate immunologically naive T cells.
Here we report that DCs that are transfected with CD95 ligand (CD95L) cDNA,
called 'killer' DCs, deliver death signals, instead of activation signals,
to T cells after antigen-specific interaction. Injection of antigen-pulsed
killer DCs into mice before sensitization induced antigen-specific immunosuppression.
When administered after sensitization, killer DCs suppressed immune responses
almost completely after subsequent challenge. Thus, killer DCs represent an
entirely new immunomodulatory protocol, which may become directly applicable
in preventing and even treating T cell-mediated inflammatory diseases.
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