Integration of endoplasmic reticulum signaling in health and disease
Meir Aridor
& William E. Balch
Departments of Cell and Molecular Biology 10550 N. Torrey Pines Road/IMMI La Jolla, California 92037, USA webalch@scripps.edu
Alteration in the endoplasmic reticulum processing of cargo molecules by
pathogens, or deficiencies in cargo handling by the endoplasmic reticulum
machinery in a broad range of diseases including cystic fibrosis, hemochromatosis
and neuropathies such as Alzheimer disease demonstrates an unanticipated role
of the endoplasmic reticulum in the control of cell fate.
