Abstract
A new study in nonhuman primates shows that long-term survival of transplanted kidneys can be achieved by mimicking the immune system's own mechanism for maintaining self tolerance (pages 686–693).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bretscher, P. & Cohn, M. A theory of self-nonself discrimination. Science 169,1042–1049 (1970).
Kirk, A.D. et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nature Med. 5, 686–693 ( 1999).
Saeland, S., Duvert, V., Moreau, I. & Banchereau, J. Human B cell precursors proliferate and express CD23 after CD40 ligation. J. Exp. Med. 178, 113–120 ( 1993).
Guerder, S. & Matzinger, P. A fail-safe mechanism for maintaining self-tolerance. J. Exp. Med. 176, 553– 564 (1992).
Ridge, J.P., Di Rosa, F. & Matzinger, P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393, 474–478 (1998).
Larsen, C.P. et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 381, 434–438 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Matzinger, P. Graft tolerance: A duel of two signals. Nat Med 5, 616–617 (1999). https://doi.org/10.1038/9458
Issue Date:
DOI: https://doi.org/10.1038/9458
