The NOD mouse model of type 1 diabetes: As good as it gets?
Mark A. Atkinson1
& Edward H. Leiter2
1
University of Florida College of Medicine, Department
of Pathology, Gainesville, Florida 32610,
USA
2
The Jackson Laboratory, Bar Harbor, Maine
04609, USA
Of the two well-known rodent models of human type 1 diabetes (the non-obese
diabetic mouse and the BioBreeding rat) the mouse has become the model of
choice. Here the authors re-examine the value of this mouse model as a tool
for understanding human diabetes and for testing potential therapies, reviewing
both strengths and weaknesses.
