Nature Medicine
5, 587 - 588 (1999)
doi:10.1038/8470
Viral receptors and vector purification: New approaches for generating clinical-grade reagentsCandace Summerford1, 2
& Richard Jude Samulski1, 21
Gene Therapy Center, 7119 Thurston-Bowles, CB 7352, Chapel Hill, North Carolina 27599, USA
2
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Correspondence should be addressed to Richard Jude Samulski RJS@med.unc.edu
REFERENCES
- Friedmann, T. in The Development of Human Gene Therapy (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1999).
- Williamsburg BioProcessing Foundation Meeting, Viral Vectors and Vaccines, (The Williamsburg Bioprocessing Foundation, Norfolk, Virginia,1998).
- Summerford, C. & Samulski, R.J. Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J. Virol. 72, 1438-1445 (1998). | PubMed | ISI | ChemPort |
- Wistuba, A., Kern, A., Weger, S., Grimm, D. & Kleinschmidt, J.A. Subcellular compartmentalization of adeno-associated virus type 2 assembly. J. Virol. 71, 1341-1352 (1997). | PubMed | ISI | ChemPort |
- Grimm, D., Kern, A., Rittner, K. & Kleinschmidt, J.A. Novel tools for production and purification of recombinant adeno-associated virus vectors. Hum. Gene Ther. 9, 2745-2760 (1998). | PubMed | ISI | ChemPort |
- Zolotukhin, S. et al. Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther. (in the press).
- Clark, K.R., Liu, X., McGrath, J.P. & Johnson, P.R. Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild type viruses. Hum. Gene Ther. (in the press).
- Xiao, X., Li, J. & Samulski, R.J. Production of high titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J. Virol. 72, 2224-2232 (1998). | PubMed | ISI | ChemPort |
- Clark, K.R., Voulgaropoulou, F., Fraley D.M., & Johnson, P.R. Cell lines for the production of infectious recombinant adeno-associated viruses. Hum. Gene Ther. 6, 1329-1341 (1995). | PubMed | ISI | ChemPort |
- Summerford, C., Bartlett, J.S. & Samulski, R.J.
 V 5 integrin: A co-receptor for adeno-associated virus type 2 infection. Nature Med. 5, 78-81 (1999). | Article | PubMed | ISI | ChemPort |
- Qing, K. et al. Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2. Nature Med. 5, 71-77 (1999). | Article | PubMed | ISI | ChemPort |
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