Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF₁₆₄ and VEGF₁₈₈

1. Ferrara, N. & Davis-Smyth, T. The biology of vascular endothelial growth factor. Endocr. Rev. 18, 4-25 (1997). | Article | PubMed  | ISI | ChemPort |
2. Isner, J.M. & Takayuki, A. Therapeutic angiogenesis. Front. Biosci. 3, e49-69 (1998). | PubMed  | ChemPort |
3. Klagsbrun, M. & D'Amore, P.A. Vascular endothelial growth factor and its receptors. Cytokine Growth Factor Rev. 7, 259-270 (1996). | Article | PubMed  | ChemPort |
4. Dvorak, H.F., Brown, L.F., Detmar, M. & Dvorak, A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146, 1029-1039 (1995). | PubMed  | ISI | ChemPort |
5. Neufeld, G., Cohen, T., Gengrinovitch, S. & Poltorak, Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13, 9-22 (1999). | PubMed  | ISI | ChemPort |
6. Keyt, B.A. et al. The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency. J. Biol. Chem. 271, 7788-7795 (1996). | Article | PubMed  | ISI | ChemPort |
7. Cheung, N., Wong, M.P., Yuen, S.T., Leung, S.Y. & Chung, L.P. Tissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colon. Hum. Pathol. 29, 910-914 (1998). | Article | PubMed  | ISI | ChemPort |
8. Soker, S., Takashima, S., Miao, H.Q., Neufeld, G. & Klagsbrun, M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform- specific receptor for vascular endothelial growth factor. Cell 92, 735-745 (1998). | Article | PubMed  | ISI | ChemPort |
9. Takeshita, S. et al. Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo. Lab. Invest. 75, 487-501 (1996). | PubMed  | ISI | ChemPort |
10. Cheng, S.Y., Nagane, M., Huang, H.S. & Cavenee, W.K. Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189. Proc. Natl. Acad. Sci. USA 94, 12081-12087 (1997). | Article | PubMed  | ChemPort |
11. Tokunaga, T. et al. Vascular endothelial growth factor (VEGF) mRNA isoform expression pattern is correlated with liver metastasis and poor prognosis in colon cancer. Br. J. Cancer 77, 998-1002 (1998). | PubMed  | ISI | ChemPort |
12. Carmeliet, P. et al. Abnormal blood vessel development and lethality in embryos lacking a single vascular endothelial growth factor allele. Nature 380, 435-439 (1996). | Article | PubMed  | ISI | ChemPort |
13. Ferrara, N. et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439-442 (1996). | Article | PubMed  | ISI | ChemPort |
14. Shima, D.T. et al. The mouse gene for vascular endothelial growth factor. Genomic structure, definition of the transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences. J. Biol Chem. 271, 3877-3883 (1996). | Article | PubMed  | ISI | ChemPort |
15. Flameng, W. et al. Relation between coronary artery stenosis and myocardial purine metabolism, histology and regional function in humans. J. Am. Coll. Cardiol. 9, 1235-1242 (1987). | PubMed  | ISI | ChemPort |
16. Vanoverschelde, J.L.J. et al. Chronic myocardial hibernation in humans. From bedside to bench. Circulation 95, 1961-1971 (1997). | PubMed  | ISI | ChemPort |
17. Elsässer, A. & Schaper, J. Hibernating myocardium: adaptation or degeneration? Basic Res. Cardiol. 90, 47-48 (1995). | PubMed  | ISI |
18. Kloner, R.A., Bolli, R., Marban, E., Reinlib, L. & Braunwald, E. Medical and cellular implications of stunning, hibernation and preconditioning. An NHLBI workshop. Circulation 97, 1848-1867 (1998). | PubMed  | ISI | ChemPort |
19. Borgers, M. in Stunning, Hibernation, and Preconditioning: Clinical Pathophysiology of Myocardial Ischemia. (eds. Heyndrickx, G.R., Vatner, S.F. & Wijns, W.) 287-306 (Lippincott-Raven, Philadelphia, 1997).
20. Schwarz, E.R. et al. Myocyte degeneration and cell death in hibernating human myocardium. J. Am. Coll. Cardiol. 27, 1577-1585 (1996). | Article | PubMed  | ISI | ChemPort |
21. Shivalkar, B. et al. Only hibernating myocardium invariably shows early recovery after coronary revascularization. Circulation 94, 308-315 (1996). | PubMed  | ISI | ChemPort |
22. Chen, C. et al. Myocardial cell death and apoptosis in hibernating myocardium. J. Am. Coll. Cardiol. 30, 1407-1412 (1997). | Article | PubMed  | ISI | ChemPort |
23. Shivalkar, B. Chronic Reversible Myocardial Dysfunction: Clinical and Experimental Studies (PhD thesis, Acta Biomedica Lovaniensa, Leuven University Press, 1998) 1-130 (see attached copies in fax dd April 2^nd 1999).
24. Hudlicka, O. & Brown, M.D. Postnatal growth of the heart and its blood vessels. J. Vasc. Res. 33, 266-287 (1996). | PubMed  | ISI | ChemPort |
25. Tomanek, R.J. Formation of the coronary vasculature: a brief review. Cardiovasc. Res. 31, E46-51 (1996). | Article | PubMed  | ISI |
26. Hirschi, K.K., Rohovsky, S.A. & D'Amore, P.A. PDGF, TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate [published erratum in J. Cell Biol. 141, 1287 (1998)]. J. Cell. Biol. 141, 805-814 (1998). | Article | PubMed  | ISI | ChemPort |
27. Koblizek, T.I., Weiss, C., Yancopoulos, G.D., Deutsch, U. & Risau, W. Angiopoietin-1 induces sprouting angiogenesis in vitro. Curr. Biol. 8, 529-532 (1998). | Article | PubMed  | ISI | ChemPort |
28. Suri, C. et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87, 1171-1180 (1996). | Article | PubMed  | ISI | ChemPort |
29. Evans, S.M. et al. Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 (2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide). Br. J. Cancer 72, 875-882 (1995). | PubMed  | ISI | ChemPort |
30. Carmeliet, P. et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation, and tumor angiogenesis. Nature 394, 485-490 (1998). | Article | PubMed  | ISI | ChemPort |
31. Zareba, W., Moss, A.J. & le Cessie, S. Dispersion of ventricular repolarization and arrhythmic cardiac death in coronary artery disease. Am. J. Cardiol. 74, 550-553 (1994). | Article | PubMed  | ISI | ChemPort |
32. Kaprielian, R.R. et al. Downregulation of immunodetectable connexin 43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle. Circulation 97, 651-660 (1998). | PubMed  | ISI | ChemPort |
33. Schaper, J. et al. Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy. Circulation 83, 504-514 (1991). | PubMed  | ISI | ChemPort |
34. Elsässer, A. et al. Hibernating myocardium. An incomplete adaptation to ischemia. Circulation 96, 2920-2931 (1997). | PubMed  | ISI |
35. Ausma, J. et al. Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat. Circulation 96, 3157-3163 (1997). | PubMed  | ISI | ChemPort |
36. Lopaschuk, G.D., Collins-Nakai, R.L. & Itoi, T. Developmental changes in energy substrate use by the heart. Cariovasc. Res. 26, 1172-1180 (1992). | ChemPort |
37. Murda'h, M.A., McKenna, W.J. & Camm, A.J. Repolarization alternans: techniques, mechanisms, and cardiac vulnerability. Pacing Clin. Electrophysiol. 20, 2641-2657 (1997). | PubMed  | ChemPort |
38. Shaw, D.B., Linker, N.J., Heaver, P.A. & Evans, R. Chronic sinoatrial disorder (sick sinus syndrome): a possible result of cardiac ischaemia. Br. Heart J. 58, 598-607 (1987). | PubMed  | ISI | ChemPort |
39. Lopaschuk, G.D. & Stanley, W.C. Glucose metabolism in the ischemic heart. Circulation 85, 313-315 (1997).
40. Kremer, C., Breier, G., Risau, W. & Plate, K.H. Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system. Cancer Res. 57, 3852-3859 (1997). | PubMed  | ISI | ChemPort |
41. Risau, W. Development and differentiation of endothelium. Kidney Int. Suppl. 67, S3-6 (1998). | Article | PubMed  | ChemPort |
42. Witzenbichler, B. et al. Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia. Am. J. Pathol. 153, 381-394 (1998). | PubMed  | ISI | ChemPort |
43. Gerber, H.P., Condorelli, F., Park, J. & Ferrara, N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J. Biol. Chem. 272, 23659-23667 (1997). | Article | PubMed  | ISI | ChemPort |
44. Carmeliet, P. et al. Role of tissue factor in embryonic blood vessel development. Nature 383, 73-75 (1996). | Article | PubMed  | ISI | ChemPort |
45. Arber, S. et al. MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell 88, 393-403 (1997). | Article | PubMed  | ISI | ChemPort |

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