Nature Medicine
5, 405 - 411 (1999)
doi:10.1038/7403
Dendritic cells directly trigger NK cell functions: Cross-talk relevant
in innate anti-tumor immune responses in vivoNadine C. Fernandez1, Anne Lozier1, Caroline Flament1, Paola Ricciardi-Castagnoli2, Dominique Bellet1, Mark Suter3, Michel Perricaudet4, Thomas Tursz, Eugene Maraskovsky5, 6
& Laurence Zitvogel11
Unité d'Immunologie, Département de Biologie
Clinique Villejuif, France
4
CNRS-UMR1582, Institut Gustave Roussy,
Villejuif, France
2
University of Milano-Bicocca, Department of Biotechnology
and Bioscience, Milan, Italy
3
University Institut for Virology, Zürich
, Switzerland
5
Department of Immunobiology, Immunex Corporation,
Seattle, Washington, 98101-2936, USA
6
Ludwig Oncology Unit, Austin and Repatriation Medical
Center, Heidelberg, Australia
Correspondence should be addressed to Laurence Zitvogel zitvogel@igr.frCytotoxic T lymphocytes and natural killer cells are essential effectors
of anti-tumor immune responses in vivo. Dendritic cells (DC) 'prime'
tumor antigen-specific cytotoxic T lymphocytes; thus, we investigated whether
DC might also trigger the innate, NK cell-mediated anti-tumor immunity. In
mice with MHC class I-negative tumors, adoptively transferred- or Flt3 ligand-expanded
DC promoted NK cell-dependent anti-tumor effects. In vitro studies
demonstrated a cell-to-cell contact between DC and resting NK cells that resulted
in a substantial increase in both NK cell cytolytic activity and IFN-
production. Thus, DC are involved in the interaction between innate and adaptive
immune responses.
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